Achieving Concentration Goals Using Parametric Compartmental Models - the Current Unimodal Gaussian Bayesian Approach
نویسنده
چکیده
This approach is the standard one when one uses parametric compartmental pharmacokinetic (PK) models. The usual parameter values are either the mean or median as the descriptor of the central tendency, and the standard deviation (SD) as the measure of dispersion. The usual distribution is the common Gaussian bell-shaped curve. Usually the mean is the central value used, and the distribution is assumed to be symmetrical about it. This approach was introduced to the pharmacokinetic community by Sheiner [1], and is one of his group's most significant contributions to the field.
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